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Biocompatibility analysis is the process of evaluating how a material interacts with biological systems. It is crucial in the development and approval of medical devices, implants, and biomaterials. The goal is to ensure that the material or device is safe, non-toxic, and compatible with the body under specific conditions of use .
- Cytotoxicity Analysis
- Genotoxicity Assay
- Hemocompatibility Analysis
- Carcinogenesis Bioassay
- Histopathology Services
Both qualitative and quantitative cytotoxicity tests will be conducted. Less than 1000 cells can be precisely counted in a quantitative MTT cytotoxicity test. The MTT is a colorimetric technique that quantifies how much mitochondial succinate dehydrogenase reduces yellow 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide. The proportion of living cells in a solution may be measured since only living cells can catalyze the cellular reduction.
Genotoxins are substances that can harm chromosome structure or DNA, leading to mutations. It may be radiation or chemical. While damage to the germ cell results in heritable disorders, damage to the somatic cells causes a variety of illnesses, including cancer. Both direct and indirect effects on DNA, such as mutation induction, mistimed event activation, and direct DNA damage that results in mutations, can be caused by genotoxicity. It directly alters cells in ways that are heritable and may be passed on to subsequent cell generations. .
Hemocompatibility analysis is essential for evaluating the compatibility of biomaterials with blood,
primarily to prevent adverse reactions including
:
Thrombosis
Coagulation
Platelets
Hematology
Complement System
Carcinogenicity is a major consideration in the assessment of risks due to environmental chemicals. The
carcinogen bioassay therefore is a very important component of the battery of toxicological tests used
in hazard evaluation.
Analytical Toxicology
In-vitro Testing
Genotoxicity Testing
Molecular and Genetic Markers
.
Histopathology services, which concentrate on the microscopic analysis of tissues to identify illnesses,
mainly malignancies and other tissue-related abnormalities.
Cytopathology
Molecular Pathology (PCR & NGS )
Flow Cytometry
.
Biocompatibility analysis ensures that medical devices and biomaterials do not induce adverse biological reactions. At Allele Life Sciences, we conduct testing , including cytotoxicity (MTT assay) , genotoxicity , and hemocompatibility to evaluate material safety, toxicity, and compatibility with human systems before clinical application .
CONTACT :
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llelelifescience
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